Meeting in the CFA1 group - Early Cancer Detection

Monday 22 June, 22 members of the DCCC ctDNA center participated in the online meeting. The meeting allowed the members to orient each other about ongoing projects focusing on early cancer detection. This was also a chance to present and discuss projects to optimize them before the next round of funding from the DCCC ctDNA research center (deadline 23 October 2020).

Professor Claus Lindberg Andersen started the meeting with a presentation of the new validation project DELFI (DNA Evaluation of fragments for early interception) based on a project published in Nature in 2019 (https://www.nature.com/articles/s41586-019-1272-6?proof=true).

The new project aims to confirm that analysis of low pass whole genome sequencing data from blood samples using the DELFI algorithm can separate blood samples from colorectal cancer patients from those of healthy controls. Moreover, the study aims to investigate if DELFI can distinguish blood samples from adenoma carries and healthy controls.

The presentation resulted in a discussion of the procedures needed to obtain the necessary approvals from the relevant Danish authorities to conduct such study, including approval to share personal data with institutions/companies outside the EU. The procedures are many and involve a range of different Danish authorities/agencies. To obtain the approvals in a reasonable time-frame, it is advisable to work on the approvals from different authorities in parallel.

When results from the DELFI study are available, they will be presented on a CFA1 meeting, or at another potentially broader meeting within the ctDNA research center.

Next, Hans Jørgen Nielsen, MD, DMSc, presented the planned “normal variation” study. This study concerns normal variation in analytes measured in blood, and used in many studies as markers of disease, for example to distinguish blood samples from healthy individuals and diseased individuals, including analytes representing cell free tumor DNA e.g. mutations, DNA fragment lengths, DNA methylation patterns etc). The study will enroll 700 FIT-negative participants in the Danish CRC screening program. The cohort is a cross-sectional representation of Danish asymptomatic individuals in the cancer relevant age-group from 50-75 years of age. The study subjects will have 3 serial blood collections performed within a 4 week period. The cohort is excellent for assessing the normal variation in markers used to detect ctDNA. It could potentially be helpful to all CFAs within the ctDNA Research Center.  Researchers who want to know more are welcome to reach out to Hans Jørgen.

In the first round of funding from the DCCC ctDNA center Professor Anders Jakobsen received funding for a project called ”Early detection of lung cancer by blood samples - A prospective national observational study”. Anders shared his application with the participants and went through the study (a project summary is on the webpage). The project is supposed to become a supplement to the screening methods used today and will hopefully help give a clear answer when the screening is otherwise inconclusive.

The meeting concluded with a run through the criteria for receiving funding from the DCCC ctDNA center. It is important to remember that only projects with a national coverage are considered for funding. The criteria’s can be found here (https://ctdna.dk/projekter/apply-for-funding) and  definition of “national coverage” can be found here: https://www.dccc.dk/siteassets/sog-stotte/for-ansogere/vejledning-til-ansogere.pdf

  • Health Economic Consultation

    As part of the national DCCC ctDNA research center all memebers have access to health economic guidance. You can book a session directly with Liza Sopina (https://portal.findresearcher.sdu.dk/en/persons/lsopina)and you can have a discussion on how health economics are incoorporated in your project. Liza is available between 10:00 and 13:00. Other times/dates can also be arranged, please contact Liza (lsopina@health.sdu.dk) directly to book. 08 Sept 15 Sept 22 Sept 29 Sept 13 Oct 20 Oct 03 Nov Please book a 1:1 consultation if you need help with: Understanding whether economic evaluation is relevant and applicable to your study/trial Planning for and integrating economic evaluation (and relevant data collection) into your study Input into protocol or funding application Planning for a sufficient budget for economic evaluation of your trial/study Any other economic evaluation-related questions you may have! The session are online.
  • Funding application deadline

    You can apply for funding through the ctDNA center for your research project focusing on ctDNA guided intervention or development of new methods or knowledge relevant for the entire center. Deadline September 26th 2022 Find more information and the applicationform here: https://ctdna.dk/projekter/projects/apply-for-funding
  • PhD course

    The ctDNA center will host a ctDNA PhD course at Sandbjerg on May 22 - 23 2023. There are room for a maximum of 20 students. More information will follow.
  • International Symposium and Annual meeting 2022

    We look forward to welcome you to the 1st International Symposium on Circulating Tumor DNA and the Annual Meeting in the Danish National Center for Circulating Tumor DNA Guided Cancer Treatment.  Date: It will take place on the 14-15th of November 2022 November 14 2022, we will have the International Symposium with talks updating us on ctDNA research internationally November 15 2022, the Annual Meeting in the ctDNA center and the meeting in the Steering Committee will take place   Place: HUONE (Amager Strandvej 390, 2770 Kastrup, Copenhagen, Denmark)Please find information about arrival and parking at the bottom of this page: Arrival information   Participation: Please register here for both days: RegistrationDeadline September 30 2022Participation is free.The International Symposium is open for everyone. The Annual Meeting is primarily for members of the DCCC ctDNA center and other interested (eg. from DCCC, The Danish Cancer Society, patient representatives)   Poster and abstract: It is possible to bring a poster. During the International Symposium there will be a poster session, and at the Annual Meeting it will be possible to look around at the posters.If you bring a poster, please submit an abstract too. Among the submitted abstracts we will select a few for a 15-minute talk at the International Symposium.It is possible to register poster and upload an abstract in the registration. Poster size: max.: W.: 92 cm, H.: 138 cm   Tentative program: The tentative programs for the International Symposium and the Annual Meeting is to be found here: 1st International Symposium on Circulating Tumor DNA Annual Meeting in the Danish National Center for Circulating Tumor DNA Guided Cancer Treatment   Contact information:Anne Lærke Lorentzen, Scientific CoordinatorE-mail: anne.lorentzen@clin.au.dkPhone: +45 78 45 53 39  
  • PhD course

    The ctDNA center will host a ctDNA PhD course at Sandbjerg 3-4 May 2022. There is room for a maximum of 20 students. You can find more information and register here: https://au.phd-courses.dk/CourseCatalog/ShowCourse/823?returnUrl=https%3A%2F%2Fau.phd-courses.dk%2FCourseCatalog%2FShowCourses%2F%3Fquery%3Dctdna%26sortOrder%3DName Remember, both to register via the link and to send your motivated application to annette@au.dk - the deadline is 28 February 2022. The center will pay for accomodation for center members.
  • Meeting in the Steering Committee

    The steering committee will meet online on Thursday the 28th of April to discuss the incoming applications for funding from the center, and the assessments from the executive committee. The meeting will be online and it is possible for members of the steering committee to transfer their votes to the chairman of the steering committee (Lars Dyrskjøt Andersen)  Deadline for application for funding is the 7th of March
  • ctDNA and CTC training school

    ctDNA and CTC training school

    The COST Action CA17118 (TRANSCOLONCAN), Tracepigen, the DCCC Nation Research Center for ctDNA guided cancer, and the European Liquid Biopsy Society invite you to apply for participation in the training school for detection and analysis of circulating tumor DNA (ctDNA) and circulating tumor cells (CTC). The training school took place at Aarhus University Hospital in Denmark on March 28-30 2022. The training school invited 35 students from all over Europe to three days of lectures, networking, and a lot of discussions.Thank you to all lecturers and participants.   Download the lectures here: Lecture_1           Lecture_2           Lecture_3                     Lecture_4 Lecture_5           Lecture_6           Lecture_7                     Lecture_8 Lecture_9 part1                           Lecture_9 part2 Lecture_10 part1                         Lecture_10 part2 Lecture_10 part3                         Lecture_10 part4 Lecture_10 part5                        Lecture_11  
  • Medical Biotechnology and Drug Development

    On February 8 2022 a group of American students studying a semester abroud at University of Copenhagen, will visit the ctDNA research center at department of molecularmedicin, AUH. They will get an introduction to the center and ctDNA based intervention studies. We are looking forward to the visit!