Clinical Focus Areas and National Infrastructure

Clinical Focus Areas

The DCCC ctDNA center has five clinical focus areas (CFA), including screening and diagnosis, treatment decisions, treatment monitoring ,residual disease detection, and relapse surveillance. All the projects under the DCCC ctDNA center are coveret by one or more of the CFAs.

Each CFA are headed by two leaders, each international capacities within the field of the CFA.. The role of the leaders are to facilitate initiation of national ctDNA studies and trials, through organization of CFA workshops and meetings, where knowledge transfer and collaborations can flourish.  

Leaders of the Clinical Focus Areas

CFA1: Early cancer detection
Claus Lindbjerg Andersen, Molecular Medicine AUH
Christina Therkildsen, Gastroenheden 360, Hvidovre Hospital

CFA2: Guiding Adjuvant Therapy decisions
Karen-Lise Garm Spindler, kræftafdelingen AUH
Morten Mau-Sørensen, Onkologisk klinik Riget

CFA3: Risk stratified postoperative recurrence surveillance
Lars Dyrskjøt Andersen, Molecular Medicine AUH
Kåre Gotschalck, organkirurgisk afdeling, Randers

CFA4: Monitoring ctDNA levels to predict therapy respons
Henrik Ditzel, Dept. oncology, OUH
Julia S. Johansen, Dept. Oncology, Herlev and Gentifte Hospital

CFA5: Identification of therapeutically actionable targets
Iben Spanggaard, onkologisk klinik, Riget
Karin Birkenkamp-Dentröder, Molecular Medicine AUH


National Infrastructure

To support the projects in the different cliinical focus areas, the ctDNA center also consist of five national infrastructures (NI). The NIs will support the research in the different projects and ensure a high scientific and clinical standard.

Leaders of National Infrastructures

NI1: Best practice for liquid biopsy collection and pre-analytical processing
Rikke Fredslund Andersen, Vejle Sygehus
Estrid Høgdall, Regionerne Bio-og Genombank

SOP for blodprøvehåndtering ved ctDNA analyse RBGB

NI2: Methods for ctDNA detection
Mads Heilskov Rasmussen, Molecular Medicine AUH
Niels Pallisgaard, Næstved Sygehus, RUC

NI3: Bioinformatic procedures and algorithms for analysis and calling of ctDNA
Søren Besenbacher, Molecular Medicine AUH
Filipe Garrett Vieira, Center for Genomic Medicine, Riget

NI4: Health Economics
Liza Sopina, DaCHE SDU
Jes Søgaard, DaCHE SDU

NI5: Education
Claus Lindbjerg Andersen, Molecular Medicine AUH
Morten Mau-Sørensen, Onkologsk klinik Riget


NI2 invite PhD students to a digital PCR introduction

Is digital PCR a part of your PhD project but you are not an expert yet? You are now able to get a thorough introduction to digital PCR  through the National Infrastructure 2 of the ctDNA center. Professor Niels Pallisgaard is ready to introduce you to digital PCR at Næstved Sygehus. Contact Niels here to arrange a visit.