National studies

FUNDED PROJECTS

Since 2020, the center has been co-financer of projects that concentrate on documenting the positive effects of using ctDNA guided cancer treatment. Explore the projects here to gain inspiration or foster new collaborations.

OPTIMISE: OPTIMIzation of Treatment SElection and Follow up in Oligometastatic Colorectal Cancer - a ctDNA Guided phase II Randomized Approach

Karen-Lise Garm Spindler
PhD, Consultant Oncology, Professor
Department of Oncology
Aarhus University Hospital

CURE: Clinical Utility of Circulating Tumor DNA in Gastro-Esophageal Cancer

Morten Mau-Sørensen
Professor
Department of Oncology
Copenhagen University Hospital (Rigshospitalet)

Circulating Tumor DNA for early Detection of Recurrence and Risk-stratification in Melanoma

Magnús Pétur Bjarnason Obinah
MD, PhD student
Department of Plastic Surgery
Herlev and Gentofte Hospital

IMPROVE-pT1: Circulating Tumor-DNA for the Proper Allocation of Completion Resection in early Colorectal Cancer

Mads Falk Klein
MD, PhD, Associate Professor
Department of Surgery
Herlev and Gentofte Hospital

NOAC 9: A Phase II Randomised Nordic Anal Cancer Group Study on Circulating Tumor DNA guided Follow-Up

Karen-Lise Garm Spindler
PhD, Consultant Oncology, Professor
Department of Oncology
Aarhus University Hospital

CIRQUESARC: A National Prospective Observational Study of Circulating Tumor DNA and Quality of Life in Sarcomas

Anders Krarup Hansen
Professor
Department of Oncology
Herlev and Gentofte Hospital

The Diverticulitis Study: Circulating tumor DNA guided vs. opportunistic colonoscopy screening for CRC detection after acute colonic diverticulitis

Claus Lindbjerg Andersen
PhD, Professor
Department of Molecylar Medicine
Aarhus University Hospital

ISCOLIM: Improving Survival of Colo-rectal Liver Metastase by RFA-mediated Immuno-stimulation

Frank Viborg Mortensen
DMSc, Professor, Consultant Surgeon
Department of Surgery, Section for HPB Surgery,
Aarhus University Hospital

Analyzing circulating tumor DNA as a marker for response to treatment in the NORDIC-SUN clinical trial

Iben Lyskjær Heimann
Associate Professor
Department of Molecular Medicine
Aarhus University Hospital

SUPE_R: Kan opfølgning efter behandling for lungekræft forbedres med analyse af cirkulerende tumor DNA?

Barbara Malene Fischer
Chief Physician, Professor
Clinical Physiology and Nuclear Medicine
Copenhagen University Hospital (Rigshospitalet)

RESPONSE: Colorectal cancer survivors’ follow-up care – now digital and need-based. A national interventional effectiveness trial for stage I and II patients

Mai-Britt Worm Ørntoft
MD, PhD, Postdoctoral Researcher
Department of Molecular Medicine
Aarhus University Hospital

OptiMeth: Optimization and standardization of ctDNA ddPCR methylation analyses

Niels Pallisgaard
Professor
Department of Pathology
Zealand University Hospital

DETECT: Early detection of lung cancer by blood samples - A prospective national observational study

Sara Witting Christensen Wen
MD, PhD
Department of Oncology
Sygehus Lillebælt, Vejle

CIRCPAC: A National Randomized Trial Investigating the Clinical Benefit of circulating tumor DNA Guided Recurrence Surveillance After Resection for Pancreatic Cancer

Julia Sidenius Johansen
Professor, MD, DMSc
Department of Oncology
Herlev and Gentofte Hospital

LUCAGEN: Early Detection of Treatment Failure by Circulating Tumor DNA in Advanced non-small Cell Lung Cancer

Julie Gehl
Professor
Department of Clinical Oncology
Zealand University Hospital

LiMe-Lung: Close Monitoring of Treatment Response of Patients with Metastatic Non-Small Cell Lung Cancer using Liquid Biopsy with focus on ctDNA methylation and ctRNA PD-L1 status

Niels Pallisgaard
Professor
Department of Pathology
Zealand University Hospital

ctDNA as Marker of Response and Recurrence in Patients with MMR-deficient Rectal Cancer Treated with Immunotherapy. A phase II Trial in Collaboration with Danish Colorectal Cancer Group (DCCG) and MOMA

Per Pfeiffer
Professor
Department of Oncology
Odense University Hospital

ctDNA analysis of rectal cancer treated in the watchful waiting setting

Torben Frøstrup Hansen
Consultant, Clinical Professor
Department of Oncology
Sygehus Lillebælt, Vejle

De novo cancer in liver transplant recipients (DETECT) – a ScandiaTransplant collaboration

Hans-Christian Pommergaard
Associate Professor
Department of Surgery and Transplantation
Copenhagen University Hospital (Rigshospitalet)

TOMBOLA: Treatment Of Metastatic Bladder cancer at the time Of biochemical reLApse following radical cystectomy

Lars Dyrskjøt Andersen
PhD, Professor
Department of Molecular Medicine
Aarhus University Hospital and Aarhus University

PRELUCA: Circulating tumor DNA guided treatment-monitoring in advanced lung cancer - a randomized interventional study

Malene Støchkel Frank
Consultant, Clinical Research Associate Professor
Department of Clinical Oncology and Palliative Care, Zealand University Hospital

Department of Clinical Medicine, Copenhagen University

Chair of Danish Society of Clinical Oncology

IMPROVE-IT2: Implementing non-invasive circulating tumor DNA analysis to optimize the operative and postoperative treatment for patients with colorectal cancer – Intervention Trial 2

Claus Lindbjerg Andersen
PhD, Professor
Department of Molecular Medicine
Aarhus University Hospital

Rectal Polyp ctDNA Study: ctDNA Assesment of Large Rectal Polyps - An Observational Cohort Study

Nis Schlesinger
Senior Consultant
Surgical Department
Bispebjerg University Hospital

Validation of ctDNA elimination during chemotherapy for anal cancer

Karen-Lise Garm Spindler
PhD, Consultant Oncology, Professor
Department of Oncology
Aarhus University Hospital